Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13989038 | 0.83 | LSS (0.43) | LSSS1PR1PPARAHDAC1HDAC8 | |
| SCHEMBL20252441 | 0.82 | EPHX2 (0.55) | HDAC8 | |
| SCHEMBL9295648 | 0.81 | KIF11 (0.51) | S1PR1PPARAHDAC1HDAC8KIF11 | |
| SCHEMBL5867321 | 0.81 | SLC2A1 (0.52) | LSS | |
| SCHEMBL4424810 | 0.81 | PPID (0.56) | S1PR1PPARARORCHDAC4PPARD | |
| SCHEMBL19460082 | 0.78 | KIF11 (0.49) | S1PR1PPARAHDAC1HDAC8KIF11 | |
| SCHEMBL4716383 | 0.78 | S1PR1 (0.46) | LSSS1PR1PPARAHDAC1HDAC8 | |
| SCHEMBL17308276 | 0.77 | KMT2A (0.49) | HDAC1HDAC8HDAC4 | |
| SCHEMBL13993816 | 0.77 | FFAR1 (0.59) | LSSS1PR1PPARAHDAC1HDAC8 | |
| SCHEMBL13993814 | 0.76 | LSS (0.47) | LSSS1PR1PPARAHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |