Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PPIB | P23284 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | PPIG | Q13427 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3730618 | 0.96 | PPID (0.51) | PPIDPPARGEPHX2PPIBPPIA | |
| SCHEMBL4716383 | 0.84 | S1PR1 (0.46) | PPARGS1PR1PPARDPPARARORC | |
| SCHEMBL12894961 | 0.83 | PPID (0.58) | PPIDPPIBPPIAPPIGMEN1 | |
| SCHEMBL13993814 | 0.83 | LSS (0.47) | S1PR1MEN1KMT2AHDAC6PPARD | |
| SCHEMBL16839663 | 0.82 | EPHX2 (0.49) | PPARGEPHX2KCNQ2KCNQ3S1PR1 | |
| SCHEMBL4899337 | 0.82 | HDAC2 (0.42) | PPIDPPIBPPIAPPIGKCNQ2 | |
| SCHEMBL6869700 | 0.82 | MAPT (0.56) | PPIDEPHX2PPIBPPIAPPIG | |
| SCHEMBL13887110 | 0.82 | L3MBTL1 (0.48) | PPIDPPIBPPIAPPIGKDM4E | |
| SCHEMBL4414052 | 0.81 | LSS (0.49) | S1PR1HDAC4PPARDPPARARORC | |
| SCHEMBL16839770 | 0.81 | EPHX2 (0.51) | PPIDPPARGEPHX2KCNQ2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |