Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1229934 | 0.95 | ALDH1A1 (0.53) | SLC2A1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL4414052 | 0.81 | LSS (0.49) | LSS | |
| SCHEMBL17308276 | 0.80 | KMT2A (0.49) | ALDH1A1MEN1KMT2ARAB9AHTT | |
| SCHEMBL18672910 | 0.79 | RAB9A (0.47) | ALDH1A1MEN1KMT2ARAB9AHTT | |
| SCHEMBL6869700 | 0.79 | MAPT (0.56) | ALDH1A1MEN1KMT2AMCHR1RAB9A | |
| SCHEMBL9294968 | 0.79 | CYP2C9 (0.56) | ALDH1A1MEN1KMT2AMCHR1CYP2C9 | |
| SCHEMBL1867796 | 0.78 | CYP2D6 (0.51) | ALDH1A1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12809403 | 0.78 | RAB9A (0.50) | ALDH1A1MCHR1RAB9AHTTNPC1 | |
| SCHEMBL11298190 | 0.77 | CHRM2 (0.56) | ALDH1A1MEN1KMT2ARAB9AHTT | |
| SCHEMBL7396543 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |