Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MGAM | O43451 | 1/20 | 0.56 |
| ▸ | SI | P14410 | 1/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526401 | 0.76 | GAA (0.52) | GAAMGAMSIMGAM2ALOX15 | |
| SCHEMBL28719372 | 0.75 | GAA (0.50) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL8636 | 0.74 | GAA (1.00) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL1331187 | 0.74 | GAA (1.00) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL1331824 | 0.74 | GAA (1.00) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL1330550 | 0.74 | GAA (1.00) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL1864301 | 0.74 | GAA (1.00) | GAAMGAMSIMGAM2ALOX15 | |
| SCHEMBL3688695 | 0.73 | LMNA (0.46) | GAAMGAMSIMGAM2ALOX15 | |
| SCHEMBL1014646 | 0.72 | GAA (0.58) | GAAMGAMSIMGAM2ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL4334303 | 0.71 | GAA (0.94) | GAAMGAMSIMGAM2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068512-A1 | 2 -AMINO-PYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS | PALAU PHARMA, S. A. (ES) | 2009-06-04 | — | — | WO | disclosed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |