Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | RORA | P35398 | 5/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.34 |
| ▸ | RORB | Q92753 | 5/20 | 0.34 |
| ▸ | PGR | P06401 | 4/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811641 | 0.78 | APP (0.49) | PPARDPGRKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL4418147 | 0.74 | PPARG (0.46) | PPARDEPHX2PGRKCNQ3KCNQ2 | |
| SCHEMBL5561770 | 0.72 | CDK4 (0.42) | PPARDRORARORCRORBPGR | |
| SCHEMBL5557629 | 0.70 | PGR (0.42) | RORARORCRORBPGRKCNQ3 | |
| SCHEMBL15601470 | 0.68 | HTR6 (0.49) | EPHX2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL15612904 | 0.66 | HDAC6 (0.49) | KCNQ3KCNQ2KCNQ4KCNQ5PLAU | |
| SCHEMBL15612769 | 0.65 | PLAU (0.55) | KCNQ3KCNQ2KCNQ4KCNQ5PLAU | |
| SCHEMBL15525692 | 0.64 | PLG (0.45) | RORCKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL4432441 | 0.64 | PGR (0.43) | RORARORCRORBPGRNR1H3 | |
| SCHEMBL15612754 | 0.63 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNQ4KCNQ5PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-B1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | disclosed |