Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811641 | 0.90 | APP (0.49) | PLAUPLGERBB2APPPPARD | |
| SCHEMBL1812436 | 0.80 | PGR (0.42) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL4943561 | 0.78 | ERBB2 (0.58) | ERBB2HTR6APPPPARDPPARA | |
| SCHEMBL5795018 | 0.75 | HTR6 (0.62) | PPARGPLAUPLGGLO1ERBB2 | |
| SCHEMBL4942869 | 0.75 | HTR6 (0.62) | PPARGPLAUPLGGLO1ERBB2 | |
| SCHEMBL4414816 | 0.74 | PPARD (0.39) | PPARGPLAUPLGERBB2APP | |
| SCHEMBL15601470 | 0.73 | HTR6 (0.49) | PPARGPLAUPLGHTR6EPHX2 | |
| SCHEMBL4943570 | 0.73 | HTR6 (0.53) | PPARGGLO1ERBB2HTR6APP | |
| SCHEMBL4990087 | 0.73 | HTR6 (0.53) | PPARGGLO1ERBB2HTR6APP | |
| SCHEMBL5557629 | 0.72 | PGR (0.42) | ERBB2PGRNR1H3KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-B1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | claimed |