Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 8/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075014 | 0.93 | KCNK3 (0.45) | PTGDR2KCNK3HTR7HTR1AHTR2A | |
| SCHEMBL2077035 | 0.84 | KCNK3 (0.51) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2075779 | 0.82 | HTR7 (0.51) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2073889 | 0.82 | HTR7 (0.56) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL4419022 | 0.81 | HTR7 (0.65) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2076212 | 0.80 | KCNK3 (0.47) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2075978 | 0.80 | KCNK3 (0.53) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2075400 | 0.78 | LMNA (0.46) | KCNK3HTR7HTR1AHTR2ACTSS | |
| SCHEMBL2075020 | 0.75 | KCNK3 (0.44) | KCNK3CTSS | |
| SCHEMBL2076503 | 0.74 | CTSS (0.46) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668014-B1 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-01-14 | — | — | EP | disclosed |
| EP-1944306-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1905774-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-04-02 | — | — | EP | disclosed |