Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 11/20 | 0.74 |
| ▸ | DAO | P14920 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423257 | 0.89 | PLA2G7 (0.76) | PLA2G7DAOMAOB | |
| SCHEMBL7011044 | 0.88 | PLA2G7 (0.78) | PLA2G7DAOSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL4418525 | 0.85 | PLA2G7 (1.00) | PLA2G7DAOMAOBMAPT | |
| SCHEMBL7585604 | 0.85 | PLA2G7 (0.78) | PLA2G7DAOLMNAHPGDMAOB | |
| SCHEMBL3545058 | 0.83 | PLA2G7 (0.71) | PLA2G7DAOLMNAHPGDMAOB | |
| SCHEMBL7011666 | 0.83 | PLA2G7 (0.71) | PLA2G7DAOMAOB | |
| SCHEMBL7008634 | 0.82 | PLA2G7 (1.00) | PLA2G7DAO | |
| SCHEMBL4419405 | 0.82 | PLA2G7 (0.73) | PLA2G7DAOMAOBMAPT | |
| SCHEMBL4949027 | 0.82 | PLA2G7 (0.70) | PLA2G7DAOLMNAHPGDMAOB | |
| SCHEMBL4418872 | 0.81 | PLA2G7 (0.72) | PLA2G7DAOLMNAHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |