Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 15/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585604 | 0.89 | PLA2G7 (0.78) | PLA2G7MAOBMAPTDAOALDH1A1 | |
| SCHEMBL7535514 | 0.85 | PLA2G7 (0.63) | PLA2G7MAOBMAPTALDH1A1LMNA | |
| SCHEMBL4423080 | 0.84 | PLA2G7 (0.72) | PLA2G7MAOBMAPT | |
| SCHEMBL4418525 | 0.84 | PLA2G7 (1.00) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL4419405 | 0.83 | PLA2G7 (0.73) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL4423257 | 0.82 | PLA2G7 (0.76) | PLA2G7MAOBDAO | |
| SCHEMBL3545058 | 0.82 | PLA2G7 (0.71) | PLA2G7MAOBMAPTDAOALDH1A1 | |
| SCHEMBL4415191 | 0.81 | PLA2G7 (0.74) | PLA2G7MAOBMAPTDAOLMNA | |
| SCHEMBL7582759 | 0.81 | PLA2G7 (0.71) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL7011666 | 0.81 | PLA2G7 (0.71) | PLA2G7MAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |