Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 14/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585604 | 0.88 | PLA2G7 (0.78) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL7007528 | 0.88 | PLA2G7 (1.00) | PLA2G7DAO | |
| SCHEMBL4423257 | 0.86 | PLA2G7 (0.76) | PLA2G7MAOBDAO | |
| SCHEMBL4415191 | 0.85 | PLA2G7 (0.74) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL4419405 | 0.85 | PLA2G7 (0.73) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL4418872 | 0.84 | PLA2G7 (0.72) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL4423080 | 0.84 | PLA2G7 (0.72) | PLA2G7MAOBMAPT | |
| SCHEMBL3545058 | 0.83 | PLA2G7 (0.71) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL7582759 | 0.83 | PLA2G7 (0.71) | PLA2G7MAOBMAPTDAO | |
| SCHEMBL7011666 | 0.83 | PLA2G7 (0.71) | PLA2G7MAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | claimed |
| EP-1296915-A1 | METHOD FOR TRANSFERRING ALKYLIDENE GROUPS TO ORGANIC COMPOUNDS | MERCK PATENT GmbH (DE) | 2003-04-02 | — | — | EP | claimed |
| US-20020120139-A1 | Pyrimidinone compounds and pharmaceutical compositions containing them | HICKEY DEIRDRE MARY BERNADETTE (GB) | 2002-08-29 | — | — | US | claimed |
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | claimed |
| WO-2002000576-A1 | METHOD FOR TRANSFERRING ALKYLIDENE GROUPS TO ORGANIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2002-01-03 | — | — | WO | claimed |
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | claimed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | claimed |
| EP-0559885-B1 | CATALYSTS AND PROCESS FOR THE PREPARATION OF SAME FOR USE IN THE POLYMERISATION OF ETHYLENE | ENICHEM POLYMERES FRANCE (FR) | 1996-04-10 | — | — | EP | claimed |
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-1296915-A1 | METHOD FOR TRANSFERRING ALKYLIDENE GROUPS TO ORGANIC COMPOUNDS | MERCK PATENT GmbH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-20020120139-A1 | Pyrimidinone compounds and pharmaceutical compositions containing them | HICKEY DEIRDRE MARY BERNADETTE (GB) | 2002-08-29 | — | — | US | disclosed |
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |
| WO-2002000576-A1 | METHOD FOR TRANSFERRING ALKYLIDENE GROUPS TO ORGANIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2002-01-03 | — | — | WO | disclosed |
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020120139-A1 | Pyrimidinone compounds and pharmaceutical compositions containing them | PLA2G7, PLA2G1B, PLA2G4C | PLA2G7 1/4885MAOB 486/4885MAPT 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.