Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430464 | 0.96 | HSP90AA1 (0.33) | HSP90AA1PLAUNSD2MKNK1MKNK2 | |
| SCHEMBL4427891 | 0.87 | SSTR5 (0.37) | KCNH2HDAC1CSF1RIRAK4MAP4K4 | |
| SCHEMBL1445071 | 0.82 | CYP2D6 (0.33) | KCNH2HDAC1 | |
| SCHEMBL4412902 | 0.82 | ACACB (0.41) | MKNK1MKNK2TTKMAP4K4IGF1R | |
| SCHEMBL4423082 | 0.82 | IRAK4 (0.33) | KCNH2CSF1RIRAK4TTKIGF1R | |
| SCHEMBL4412864 | 0.80 | SSTR5 (0.34) | WNT1GSK3BDYRK1A | |
| SCHEMBL4416789 | 0.79 | ACACB (0.38) | MKNK1MKNK2CSF1RMAP4K4FGFR1 | |
| SCHEMBL4423563 | 0.78 | TTK (0.33) | TTKWNT1GSK3BDYRK1A | |
| SCHEMBL4423456 | 0.78 | S1PR1 (0.34) | CSF1RIRAK4TTKMAP4K4WNT1 | |
| SCHEMBL4427980 | 0.78 | GSK3B (0.33) | MKNK1MKNK2CSF1RIRAK4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | claimed |