Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794184 | 0.94 | CNR2 (0.48) | CNR2TSHRRIPK1 | |
| SCHEMBL3799616 | 0.74 | CNR2 (0.59) | CNR2TSHR | |
| SCHEMBL3800355 | 0.72 | CNR2 (0.44) | CNR2 | |
| SCHEMBL3797729 | 0.70 | CNR2 (0.45) | CNR2TSHR | |
| SCHEMBL8048547 | 0.70 | TSHR (0.39) | TSHRHTT | |
| SCHEMBL3141139 | 0.69 | CES2 (0.34) | — | |
| SCHEMBL11365709 | 0.68 | ATM (0.44) | CNR2 | |
| SCHEMBL10179743 | 0.68 | CES2 (0.42) | RIPK1 | |
| SCHEMBL14035562 | 0.65 | CNR2 (0.45) | CNR2TSHR | |
| SCHEMBL31292359 | 0.65 | CNR2 (0.45) | CNR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120898-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077009-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |