Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884029 | 0.77 | CRHBP (0.53) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL14510437 | 0.75 | TSHR (0.50) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL12346186 | 0.75 | CYP2C19 (0.56) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL8773449 | 0.75 | CRHBP (0.50) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL28813822 | 0.74 | CRHBP (0.53) | CRHBPCRHR2PTPN1ALDH1A1CYP2C19 | |
| SCHEMBL2887865 | 0.74 | CRHBP (0.49) | CRHBPCRHR2PTPN1ALDH1A1RAB9A | |
| SCHEMBL3632685 | 0.73 | CRHBP (0.46) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL3632686 | 0.73 | CRHBP (0.46) | CRHBPCRHR2TSHRPTPN1ALDH1A1 | |
| SCHEMBL8272263 | 0.72 | NLRP3 (0.49) | CRHBPCRHR2TSHRLMNAPTPN1 | |
| SCHEMBL1927316 | 0.72 | TDP1 (0.57) | TSHRALDH1A1GLARAB9ATSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742945-B1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | BAYER SCHERING PHARMA AG (DE) | 2009-12-30 | — | — | EP | disclosed |
| EP-1742945-A1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | Bayer HealthCare AG (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108397-A1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2005-11-17 | — | — | WO | disclosed |