Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852240 | 0.89 | ALDH1A1 (0.59) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL6813826 | 0.88 | ALDH1A1 (0.56) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL11565369 | 0.83 | LRRK2 (0.59) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL4416634 | 0.83 | FOLH1 (0.58) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL11563262 | 0.83 | MAOB (0.56) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL853069 | 0.82 | FOLH1 (0.57) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL1646582 | 0.82 | RXRA (0.56) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL5431545 | 0.82 | LRRK2 (0.63) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL6680832 | 0.82 | HPGD (0.51) | ALDH1A1KDM4EPOLBL3MBTL1HPGD | |
| SCHEMBL9789583 | 0.82 | PTGER1 (0.61) | HPGDLMNACYP2C9KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | claimed |
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | disclosed |
| CN-1208314-C | Factor VIIA inhibitor (thio) urea derivatives, their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2005-06-29 | — | — | CN | disclosed |
| CN-1427818-A | Factor VIIA inhibitor (thio) urea derivatives, their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2003-07-02 | — | — | CN | disclosed |