Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1086772 | 0.88 | KMT2A (0.52) | ALDH1A1TSHRGAAEPAS1LMNA | |
| SCHEMBL1086265 | 0.82 | LMNA (0.59) | ALDH1A1SMN1; SMN2TSHRGAAEPAS1 | |
| SCHEMBL1086176 | 0.82 | EPAS1 (0.56) | ALDH1A1SMN1; SMN2TSHRGAAEPAS1 | |
| SCHEMBL1086202 | 0.79 | TACR1 (0.44) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL1086458 | 0.78 | KMT2A (0.56) | SMN1; SMN2TSHRGAALMNAKMT2A | |
| SCHEMBL1086278 | 0.76 | KMT2A (0.60) | SMN1; SMN2TSHRGAALMNAKMT2A | |
| SCHEMBL1086304 | 0.74 | MEN1 (0.41) | ALDH1A1SMN1; SMN2TSHRGAAHTT | |
| SCHEMBL1086619 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL1086045 | 0.74 | KMT2A (0.54) | SMN1; SMN2TSHRGAALMNAKMT2A | |
| SCHEMBL1086560 | 0.73 | RAB9A (0.44) | ALDH1A1SMN1; SMN2HTTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |