SCHEMBL4417331

SCHEMBL4417331

CN(Cc1ccccc1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.71

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 5/20 0.71
NR1H3 Q13133 5/20 0.71
MTOR P42345 1/20 0.52
TMEM97 Q5BJF2 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
PYCR1 P32322 1/20 0.46
ALDH1A1 P00352 2/20 0.45
TSHR P16473 2/20 0.45
DHFR P00374 3/20 0.45
CRHBP P24387 1/20 0.45
CRHR2 Q13324 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
KIF11 P52732 1/20 0.44
OPRM1 P35372 1/20 0.44
OPRL1 P41146 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28281535 0.93 NR1H2 (0.62) NR1H2NR1H3MTORTMEM97SIGMAR1
SCHEMBL11881187 0.84 NR1H2 (0.62) NR1H2NR1H3PYCR1ALDH1A1TSHR
SCHEMBL8697928 0.84 NR1H2 (0.56) NR1H2NR1H3MTORALDH1A1TSHR
SCHEMBL4628014 0.83 NR1H3 (1.00) NR1H2NR1H3
SCHEMBL27706495 0.83 NR1H3 (0.56) NR1H2NR1H3MTORTMEM97SIGMAR1
SCHEMBL17193573 0.81 PYCR1 (0.62) NR1H2NR1H3MTORTMEM97SIGMAR1
SCHEMBL642317 0.80 CRHBP (0.61) NR1H2NR1H3PYCR1ALDH1A1TSHR
SCHEMBL6982805 0.79 NR1H2 (0.58) NR1H2NR1H3ALDH1A1TSHRCRHBP
SCHEMBL10933832 0.79 NR1H2 (0.59) NR1H2NR1H3ALDH1A1TSHRCRHBP
Hydrochloric Acid SCHEMBL27388371 0.78 CRHBP (0.59) NR1H2NR1H3PYCR1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111074370-B Low-melting-point chinlon thermal fuse and preparation method thereof 温州大学 2022-05-20 CN claimed
CN-111074370-A Low-melting-point chinlon hot melt yarn and preparation method thereof 温州大学 2020-04-28 CN claimed
CN-116926693-A High-thermal-adhesiveness thermal fuse manufacturing system and manufacturing method thereof 浙江及时宇新材料有限公司 2023-10-24 CN disclosed
CN-110818576-B Secondary amine derivative synthesized by rare earth catalysis and preparation method thereof 温州大学 2023-02-24 CN disclosed
CN-111074370-B Low-melting-point chinlon thermal fuse and preparation method thereof 温州大学 2022-05-20 CN disclosed
CN-111074370-B Low-melting-point chinlon thermal fuse and preparation method thereof 温州大学 2022-05-20 CN disclosed
CN-111074370-A Low-melting-point chinlon hot melt yarn and preparation method thereof 温州大学 2020-04-28 CN disclosed
CN-111074370-A Low-melting-point chinlon hot melt yarn and preparation method thereof 温州大学 2020-04-28 CN disclosed
CN-110818576-A Secondary amine derivative synthesized by rare earth catalysis and preparation method thereof 温州大学 2020-02-21 CN disclosed
EP-1479671-B1 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2009-05-27 EP disclosed