Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | RORA | P35398 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | RORB | Q92753 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803545 | 0.83 | MLYCD (0.58) | MLYCDHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4414741 | 0.82 | MAPK14 (0.42) | MLYCDMAPK14BRD4HDAC1HDAC2 | |
| SCHEMBL4418588 | 0.81 | MLYCD (0.57) | MLYCDPPARGHDAC1HDAC2HDAC8 | |
| SCHEMBL1807511 | 0.79 | MLYCD (0.42) | MLYCDEPHX2PPARGMAPK14BRD4 | |
| SCHEMBL1804344 | 0.79 | MLYCD (0.46) | MLYCDPPARGNR1H2NR1H3 | |
| SCHEMBL1811315 | 0.77 | CCR2 (0.51) | BRD4HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4420743 | 0.77 | HSD11B1 (0.45) | MLYCDEPHX2PPARGRORARORC | |
| SCHEMBL4421334 | 0.77 | CDK4 (0.55) | MLYCD | |
| SCHEMBL4415610 | 0.77 | MLYCD (0.44) | MLYCDPPARGBRD4HDAC1HDAC2 | |
| SCHEMBL1813000 | 0.75 | F10 (0.48) | BRD4HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-B1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | claimed |