Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2793083 | 0.85 | HSD11B1 (0.46) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL18390864 | 0.78 | HSD11B1 (0.73) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL2790694 | 0.78 | MC4R (0.55) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL18390860 | 0.76 | MEN1 (0.74) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL18390861 | 0.76 | MEN1 (0.69) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL18390061 | 0.74 | MEN1 (0.77) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL3396545 | 0.73 | MC4R (0.55) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL14289421 | 0.73 | HSD11B1 (0.79) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL2790450 | 0.73 | CACNA2D1 (0.55) | HSD11B1MEN1KMT2A | |
| SCHEMBL18390066 | 0.72 | ALDH1A1 (0.74) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061780-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-05-27 | — | — | EP | claimed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | claimed |