Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12195584 | 0.77 | HPGD (1.00) | ALDH1A1HPGDSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL166484 | 0.76 | LMNA (0.82) | ALDH1A1HPGDSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL8722201 | 0.76 | SMN1; SMN2 (0.69) | ALDH1A1HPGDSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL18415475 | 0.76 | SMN1; SMN2 (1.00) | ALDH1A1SMN1; SMN2RAB9AKMT2APOLB | |
| SCHEMBL21065524 | 0.76 | SMN1; SMN2 (0.79) | ALDH1A1SMN1; SMN2RAB9AKMT2APOLB | |
| SCHEMBL29460273 | 0.76 | SMN1; SMN2 (0.79) | ALDH1A1SMN1; SMN2RAB9AKMT2APOLB | |
| SCHEMBL30522589 | 0.76 | SMN1; SMN2 (1.00) | ALDH1A1SMN1; SMN2RAB9AKMT2APOLB | |
| SCHEMBL4411701 | 0.75 | HSD17B10 (0.59) | ALDH1A1SMN1; SMN2MAPK1POLBLMNA | |
| Hydrochloric Acid SCHEMBL27843329 | 0.75 | LMNA (0.80) | ALDH1A1HPGDSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL18031536 | 0.75 | LMNA (0.74) | ALDH1A1HPGDSMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |