Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418772 | 0.81 | NPSR1 (0.63) | ALDH1A1SMN1; SMN2GAAMMP13LMNA | |
| SCHEMBL4439118 | 0.77 | KEAP1 (0.51) | HSD17B10ALDH1A1ACE2GAAMAPK1 | |
| SCHEMBL13702379 | 0.77 | KMT2A (0.51) | HSD17B10ALDH1A1ACE2GAAMAPK1 | |
| SCHEMBL1569157 | 0.77 | L3MBTL1 (0.77) | HSD17B10ALDH1A1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL1570163 | 0.76 | ACE2 (0.48) | ALDH1A1ACE2SMN1; SMN2GAAKEAP1 | |
| SCHEMBL4417846 | 0.75 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1SMN1; SMN2MAPK1MAPK14 | |
| SCHEMBL13101027 | 0.75 | ACE2 (0.49) | HSD17B10ALDH1A1ACE2GAAMAPK1 | |
| SCHEMBL12223956 | 0.75 | POLB (0.57) | ALDH1A1ACE2SMN1; SMN2GAAMAPK1 | |
| SCHEMBL159413 | 0.74 | — | — | |
| SCHEMBL22875492 | 0.74 | ACE2 (1.00) | ACE2L3MBTL1SMN1; SMN2GAAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |