Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412422 | 0.99 | RAB9A (0.51) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5593266 | 0.95 | RAB9A (0.50) | RAB9ANPC1RAF1BRAFMAPK14 | |
| SCHEMBL14473018 | 0.88 | RAB9A (0.50) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4565287 | 0.87 | RAB9A (0.47) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4417865 | 0.86 | BRAF (0.47) | RAB9ANPC1SMN1; SMN2RAF1BRAF | |
| SCHEMBL4410231 | 0.85 | BRAF (0.48) | RAB9ANPC1SMN1; SMN2RAF1BRAF | |
| SCHEMBL4411709 | 0.85 | RIPK2 (0.47) | RAB9ANPC1SMN1; SMN2RAF1BRAF | |
| SCHEMBL5592981 | 0.84 | RAF1 (0.54) | RAB9ANPC1RAF1BRAFMAPK14 | |
| SCHEMBL4551384 | 0.84 | RAF1 (0.52) | RAB9ANPC1RAF1BRAFMAPK14 | |
| SCHEMBL4410928 | 0.84 | RIPK2 (0.48) | RAB9ANPC1SMN1; SMN2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |