Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3
The experimentally established mechanism targets of Carvedilol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 0.98 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.98 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.98 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.98 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.98 |
| ▸ | DRD2 | P14416 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 2/20 | 0.98 |
| ▸ | TLR4 | O00206 | 2/20 | 0.98 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | MLNR | O43193 | 1/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | APP | P05067 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carvedilol SCHEMBL19712689 | 1.00 | ADRB2 (0.98) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL4412664 | 1.00 | ADRB2 (0.98) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1785549 | 0.99 | ADRB2 (0.96) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1784597 | 0.99 | ADRB2 (0.96) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1172788 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL10082334 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL29370188 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| (R)-Carvedilol SCHEMBL232110 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| (R)-Carvedilol SCHEMBL29382761 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 | |
| Carvedilol SCHEMBL1560204 | 0.99 | ADRB2 (1.00) | ADRB2DRD2MAPTTLR4DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691789-B1 | CARVEDILOL FREE BASE, SALTS, ANHYDROUS FORMS OR SOLVATE THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULATIONS, AND TREATMENT OR DELIVERY METHODS | SMITHKLINE BEECHAM (CORK) LTD (IE) | 2017-12-20 | — | — | EP | claimed |
| US-20090326033-A1 | Carvedilol | HILDESHEIM JEAN | 2009-12-31 | — | — | US | claimed |
| CN-103373952-B | New crystal forms of carvedilol sulfate | 江苏恒瑞医药股份有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-103373952-A | New crystal forms of carvedilol sulfate | JIANGSU HENGRUI MEDICINE CO | 2013-10-30 | — | — | CN | disclosed |
| EP-1432681-B1 | PSEUDOPOLYMORPHIC FORMS OF CARVEDILOL | HOFFMANN LA ROCHE (CH) | 2007-08-08 | — | — | EP | disclosed |
| US-20060148878-A1 | Pseudopolymorphic forms of carvedilol | SB PHARMCO PUERTO RICO INC. (PR) | 2006-07-06 | — | — | US | disclosed |
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20040198812-A1 | Pseudopolymorphic forms of carvedilol | SB PHARMCO PUERTO RICO INC. (PR) | 2004-10-07 | — | — | US | disclosed |
| EP-1432681-A1 | PSEUDOPOLYMORPHIC FORMS OF CARVEDILOL | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-30 | — | — | EP | disclosed |
| US-20030119893-A1 | Pseudopolymorphic forms of carvedilol | SB PHARMCO PUERTO RICO INC. (PR) | 2003-06-26 | — | — | US | disclosed |
| WO-2003029214-A1 | PSEUDOPOLYMORPHIC FORMS OF CARVEDILOL | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326033-A1 | Carvedilol | REN, ADRB1, ADRB2 | ADRB2 3/4885ADRB1 2/4885ADRB3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.