Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155051 | 0.93 | TAAR1 (0.60) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL6252163 | 0.91 | KDM4E (0.58) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| SCHEMBL13456504 | 0.88 | TAAR1 (0.56) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| SCHEMBL13184538 | 0.88 | KDM4E (0.59) | LOXL2KDM4ECYP3A4MAPTADRB2 | |
| SCHEMBL12635837 | 0.81 | LTA4H (0.54) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| SCHEMBL28648991 | 0.81 | LOXL2 (0.59) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| SCHEMBL6414198 | 0.81 | PRMT6 (0.65) | TAAR1KDM4ECYP3A4MAPTNOS3 | |
| SCHEMBL2504209 | 0.80 | KDM4E (0.68) | TAAR1LOXL2KDM4ECYP3A4MAPT | |
| SCHEMBL4418262 | 0.79 | GRM2 (0.46) | TAAR1LMNALOXL2KDM4ECYP3A4 | |
| SCHEMBL23512484 | 0.79 | MAPT (0.50) | TAAR1LMNALOXL2KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103242273-A | 2-arylbenzofuran-7-methanamide compound, preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2013-08-14 | — | — | CN | disclosed |
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |