Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314298 | 0.89 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4ESLC6A7LMNA | |
| SCHEMBL4419677 | 0.85 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ESLC6A7 | |
| SCHEMBL4324183 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ESLC6A7 | |
| SCHEMBL4324152 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ESLC6A7TLR8 | |
| SCHEMBL4318575 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ESLC6A7LMNA | |
| SCHEMBL4319212 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ESLC6A7L3MBTL1 | |
| SCHEMBL4324188 | 0.83 | SLC6A7 (0.57) | ALDH1A1HPGDKDM4ESLC6A7SMN1; SMN2 | |
| SCHEMBL4326163 | 0.83 | L3MBTL1 (0.60) | ALDH1A1HPGDKDM4ESLC6A7L3MBTL1 | |
| SCHEMBL4326152 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4ESLC6A7 | |
| SCHEMBL4319866 | 0.82 | SLC6A7 (0.62) | ALDH1A1HPGDKDM4ESLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | ALDH1A1 3104/4885HPGD 2657/4885KDM4E 1411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.