Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990860 | 1.00 | GAA (0.72) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12486937 | 0.98 | LMNA (0.71) | GAALMNAALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL12487282 | 0.96 | LMNA (0.74) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL15797438 | 0.86 | GAA (0.55) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL1808956 | 0.85 | GAA (0.96) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL15063248 | 0.85 | GAA (0.96) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL2554530 | 0.85 | GAA (0.96) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL628011 | 0.85 | GAA (0.96) | GAALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL4777610 | 0.84 | GAA (0.51) | GAALMNAALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2988022 | 0.84 | GAA (1.00) | GAALMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507212-B1 | PROCESS FOR PREPARING METHYL PHENIDATE HYDROCHLORIDE | HARMAN FINOCHEM LTD (IN) | 2014-04-16 | — | — | EP | claimed |
| EP-1633348-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004098589-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARMACEUTICALS, INC. (US) | 2004-11-18 | — | — | WO | claimed |
| US-20030049807-A1 | Micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | INSTITUTO BIOCHIMICO ITALIANO GIOVANNI LOREZINI S.P.A. (IT) | 2003-03-13 | — | — | US | claimed |
| EP-1291435-A2 | A micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 2003-03-12 | — | — | EP | claimed |
| US-9512077-B2 | Process for the preparation of methylphenidate hydrochloride and its intermediates thereof | ZCL CHEMICALS LTD. (IN) | 2016-12-06 | — | — | US | disclosed |
| US-9475770-B2 | Low-temperature synthesis of methylphenidate hydrochloride | RHODES TECHNOLOGIES (US) | 2016-10-25 | — | — | US | disclosed |
| CN-103298785-B | Low Temperature Synthesis of Methylphenidate Hydrochloride | RHODES TECHNOLOGIES (US) | 2016-04-20 | — | — | CN | disclosed |
| EP-2937336-A1 | LOW-TEMPERATURE SYNTHESIS OF METHYLPHENIDATE HYDROCHLORIDE | Rhodes Technologies (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2651892-B1 | LOW-TEMPERATURE SYNTHESIS OF METHYLPHENIDATE HYDROCHLORIDE | RHODES TECHNOLOGIES (US) | 2015-04-22 | — | — | EP | disclosed |
| US-20150051400-A1 | A PROCESS FOR THE PREPARATION OF METHYLPHENIDATE HYDROCHLORIDE AND ITS INTERMEDIATES THEREOF | COHANCE LIFESCIENCES LIMITED (IN) | 2015-02-19 | — | — | US | disclosed |
| US-20150038720-A1 | Low-Temperature Synthesis of Methylphenidate Hydrochloride | RHODES TECHNOLOGIES (US) | 2015-02-05 | — | — | US | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| US-7002016-B2 | Process for the preparation of threo-methylphenidate hydrochloride | ISP INVESTMENTS INC. (US) | 2006-02-21 | — | — | US | disclosed |
| WO-2004080583-A2 | PROCESS FOR THE PREPARATION OF threo-METHYLPHENIDATE HYDROCHLORIDE | ISP INVESTMENTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004080959-A2 | PROCESS FOR THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE | ISP INVESTMENTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | ISP INVESTMENTS INC. | 2004-09-09 | — | — | US | disclosed |
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| US-20030049807-A1 | Micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | INSTITUTO BIOCHIMICO ITALIANO GIOVANNI LOREZINI S.P.A. (IT) | 2003-03-13 | — | — | US | disclosed |
| EP-1291435-A2 | A micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | COMT, METTL3, SLC6A3 | GAA 665/4885LMNA 4656/4885ALDH1A1 241/4885 |
| US-20150038720-A1 | Low-Temperature Synthesis of Methylphenidate Hydrochloride | COMT, CYP3A43, CYP3A4 | GAA 265/4885LMNA 3814/4885ALDH1A1 712/4885 |
| US-20150051400-A1 | A PROCESS FOR THE PREPARATION OF METHYLPHENIDATE HYDROCHLORIDE AND ITS INTERMEDIATES THEREOF | COMT, CYP3A4, CYP3A43 | GAA 93/4885LMNA 3168/4885ALDH1A1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.