Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 4/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TK1 | P04183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419221 | 0.87 | ALB (0.40) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4413022 | 0.87 | DNMT1 (0.32) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4563333 | 0.85 | DNMT1 (0.30) | DNMT1ADRB1 | |
| SCHEMBL5976411 | 0.81 | PDE4D (0.35) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL28976992 | 0.72 | PDE4D (0.37) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6351546 | 0.71 | ALB (0.42) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL9446590 | 0.70 | PDE4D (0.35) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL7128276 | 0.68 | DNMT1 (0.32) | DNMT1ADRB1 | |
| SCHEMBL3449198 | 0.68 | PDE3A (0.46) | DNMT1ADRB1SMN1; SMN2LMNAPOLB | |
| SCHEMBL28114849 | 0.67 | DNMT1 (0.32) | DNMT1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252768-B2 | Designer therapy of pancreatic tumors | UNIVERSITY OF MIAMI (US) | 2012-08-28 | — | — | US | disclosed |
| US-20090325897-A1 | DESIGNER THERAPY OF PANCREATIC TUMORS | UNIVERSITY OF MIAMI (US) | 2009-12-31 | — | — | US | disclosed |
| WO-2008085611-A2 | DESIGNER THERAPHY OF PANCREATIC TUMORS | UNIVERSITY OF MIAMI (US) | 2008-07-17 | — | — | WO | disclosed |