SCHEMBL441932

SCHEMBL441932

O=C(CCCC(=O)Nc1cccc(O)c1)Nc1cccc(O)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 3/20 0.67
POLB P06746 1/20 0.62
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
ALDH1A1 P00352 1/20 0.59
CYP1A2 P05177 1/20 0.59
NLRP3 Q96P20 6/20 0.58
HDAC3 O15379 2/20 0.55
HDAC1 Q13547 2/20 0.55
HDAC7 Q8WUI4 2/20 0.55
HDAC2 Q92769 2/20 0.55
HDAC10 Q969S8 2/20 0.55
HDAC11 Q96DB2 2/20 0.55
HDAC8 Q9BY41 2/20 0.55
HDAC6 Q9UBN7 2/20 0.55
HDAC9 Q9UKV0 2/20 0.55
HDAC5 Q9UQL6 2/20 0.55
PARP1 P09874 1/20 0.55
PARP10 Q53GL7 1/20 0.55
CNR1 P21554 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL439465 0.96 HDAC4 (0.71) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL13263766 0.90 KDM4E (0.65) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL5699578 0.90 HDAC4 (0.68) HDAC4POLBMEN1KMT2AALDH1A1
Hydrochloric Acid SCHEMBL15284015 0.89 HDAC4 (0.67) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL11132798 0.89 HDAC4 (0.63) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL13233238 0.87 HDAC4 (0.65) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL7093999 0.87 ALDH1A1 (0.58) HDAC4POLBMEN1KMT2AALDH1A1
SCHEMBL8388528 0.87 HDAC4 (0.65) HDAC4POLBALDH1A1CYP1A2NLRP3
SCHEMBL21234556 0.87 HDAC4 (0.65) HDAC4POLBALDH1A1CYP1A2NLRP3
SCHEMBL28732582 0.87 HDAC4 (0.65) HDAC4POLBALDH1A1CYP1A2NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0542972-B1 HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS DOW CHEMICAL CO (US) 1997-11-05 EP claimed
US-5134218-A Hydroxy-functional poly(amide ethers) as thermoplastic barrier resins THE DOW CHEMICAL COMPANY (US) 1992-07-28 US claimed
EP-1692208-B1 WATER-SOLUBLE POLYHYDROXYAMINOETHER AND PROCESS FOR PREPARING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-05 EP disclosed
WO-2015107490-A1 ANTI-GEL AGENT FOR POLYHYDROXYETHERAMINES, GEL STABILIZED POLYHYDROXYAMINOETHER SOLUTIONS, AND METHODS FOR MAKING AND USING SAME CLEARWATER INTERNATIONAL, LLC (US) 2015-07-23 WO disclosed
US-20150197682-A1 ANTI-GEL AGENT FOR POLYHYDROXYETHERAMINES, GEL STABILIZED POLYHYDROXYETHERAMINE SOLUTIONS, AND METHODS FOR MAKING AND USING SAME Lubrizol Oilfield Solutions, Inc. 2015-07-16 US disclosed
US-8551589-B2 Mono and multi-layer articles and extrusion methods of making the same THE CONCENTRATE MANUFACTURING COMPANY OF IRELAND (BM) 2013-10-08 US disclosed
US-20120082810-A1 WATER-RESISTANT COATED ARTICLES AND METHODS OF MAKING SAME ADVANCED PLASTICS TECHNOLOGIES LUXEMBOURG S.A. (LU) 2012-04-05 US disclosed
US-20120061344-A1 Mono and Multi-Layer Articles and Injection Molding Methods of Making the Same THE CONCENTRATE MANUFACTURING COMPANY OF IRELAND (BM) 2012-03-15 US disclosed
US-8017063-B2 Molds and methods for injection molding preforms THE CONCENTRATE MANUFACTURING COMPANY OF IRELAND (BM) 2011-09-13 US disclosed
US-20110200827-A1 WATER-RESISTANT COATED ARTICLES AND METHODS OF MAKING SAME HUTCHINSON GERALD A 2011-08-18 US disclosed
US-20110180509-A1 MONO AND MULTI-LAYER ARTICLES AND EXTRUSION METHODS OF MAKING THE SAME THE CONCENTRATE MANUFACTURING COMPANY OF IRELAND (BM) 2011-07-28 US disclosed
US-5686551-A DIHYDROXYSTILBENES, DIGLYCIDYL ETHERS THE DOW CHEMICAL COMPANY (US) 1997-11-11 US disclosed
EP-0542972-B1 HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS DOW CHEMICAL CO (US) 1997-11-05 EP disclosed
US-5464924-A Flexible films of polyethers with oxygen barriers THE DOW CHEMICAL COMPANY (US) 1995-11-07 US disclosed
US-5458258-A Storage tanks for compressed natural gas with a hydroxy-phenoxyether polymer barrier liner THE DOW CHEMICAL COMPANY (US) 1995-10-17 US disclosed
US-5401814-A Catalytic reaction of a dihydric phenol and diepoxy compound and cationic ammonium or phosphonium compounds in solvents THE DOW CHEMICAL COMPANY (US) 1995-03-28 US disclosed
US-5391650-A Amorphous, low viscosity and self-curing; workability; molding materials; composites; adhesives; binders; coatings; heat resistance THE DOW CHEMICAL COMPANY (US) 1995-02-21 US disclosed
EP-0542972-A1 HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS THE DOW CHEMICAL COMPANY (US) 1993-05-26 EP disclosed
WO-1992021707-A1 HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS THE DOW CHEMICAL COMPANY (US) 1992-12-10 WO disclosed
US-5134218-A Hydroxy-functional poly(amide ethers) as thermoplastic barrier resins THE DOW CHEMICAL COMPANY (US) 1992-07-28 US disclosed