Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | SLC26A3 | P40879 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799950 | 0.92 | RXRB (0.49) | PTGER1RXRARXRBRXRGPTPN1 | |
| SCHEMBL3795791 | 0.87 | KDM1A (0.64) | KDM1APTGER1NPC1MRGPRX4LRRK2 | |
| SCHEMBL3954112 | 0.77 | S1PR5 (0.60) | PTGER1RXRARXRBRXRGNPC1 | |
| SCHEMBL29510818 | 0.77 | S1PR5 (0.60) | PTGER1RXRARXRBRXRGNPC1 | |
| SCHEMBL13014915 | 0.77 | THRA (0.52) | KDM1APTGER1RXRARXRBRXRG | |
| SCHEMBL5527936 | 0.76 | PKM (0.53) | PTPN1 | |
| SCHEMBL24277672 | 0.75 | PTPN1 (0.56) | PTGER1RXRARXRBRXRGPTPN1 | |
| SCHEMBL17893533 | 0.75 | KDM1A (0.51) | KDM1APTGER1 | |
| SCHEMBL28759062 | 0.75 | FFAR1 (0.51) | KDM1APTGER1RXRARXRBRXRG | |
| SCHEMBL25337360 | 0.74 | MRGPRX4 (0.59) | PTGER1NPC1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120898-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077009-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |