Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709033 | 0.75 | HRH4 (0.52) | HRH3HRH4 | |
| SCHEMBL1773838 | 0.75 | LMNA (0.51) | HRH3AURKAPDPK1AURKB | |
| SCHEMBL6510068 | 0.73 | HRH4 (0.55) | HRH3HRH4AURKAPDPK1AURKB | |
| SCHEMBL1990283 | 0.73 | HRH3 (0.48) | HRH3HRH4AURKAPDPK1AURKB | |
| SCHEMBL4420312 | 0.73 | HRH3 (0.57) | HRH3HRH4AURKAPDPK1AURKB | |
| SCHEMBL14574680 | 0.72 | HRH3 (0.56) | HRH3HRH4AURKAPDPK1AURKB | |
| SCHEMBL1775397 | 0.70 | HRH4 (0.54) | HRH3HRH4 | |
| SCHEMBL23931281 | 0.70 | PDPK1 (0.43) | HRH3HRH4AURKAPDPK1AURKB | |
| SCHEMBL3717204 | 0.69 | HRH4 (0.52) | HRH3HRH4 | |
| SCHEMBL3717198 | 0.69 | HRH4 (0.52) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068512-A1 | 2 -AMINO-PYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS | PALAU PHARMA, S. A. (ES) | 2009-06-04 | — | — | WO | disclosed |