Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023054 | 0.91 | HTR3A (0.54) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL605156 | 0.86 | HRH3 (0.62) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL23931281 | 0.82 | PDPK1 (0.43) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL1773838 | 0.80 | LMNA (0.51) | LMNAHTTHRH3AURKAPDPK1 | |
| SCHEMBL23931287 | 0.80 | HRH3 (0.39) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL6023493 | 0.79 | JAK2 (0.45) | HRH4HTR3ALMNAUSP2TSHR | |
| Hydrochloric Acid SCHEMBL602600 | 0.79 | HTR3A (0.58) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL6512558 | 0.78 | LMNA (0.56) | HRH4HTR3ALMNAUSP2TSHR | |
| SCHEMBL4420312 | 0.78 | HRH3 (0.57) | HRH4HRH3AURKAPDPK1AURKB | |
| SCHEMBL1990283 | 0.78 | HRH3 (0.48) | HRH4LMNAHRH3AURKAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005054239-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-06-16 | — | — | WO | disclosed |