Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | AOC1 | P19801 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409210 | 0.86 | HTT (0.39) | GPR119HTTCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL846286 | 0.82 | GPR119 (0.44) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL15899185 | 0.78 | GPR119 (0.43) | GPR119KCNH2 | |
| SCHEMBL31421458 | 0.76 | CYP2D6 (0.47) | GPR119HTTCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL14825828 | 0.76 | HTT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL3822143 | 0.76 | CYP2E1 (0.57) | GPR119HTTCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL3280015 | 0.76 | HTT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL3280017 | 0.76 | NCOA3 (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL10526908 | 0.76 | HTT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL1447858 | 0.76 | HTT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040698-A2 | OXIME COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008008398-A2 | OXIME COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2008-01-17 | — | — | WO | disclosed |