Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100727 | 0.86 | CYP11B1 (0.39) | GPR119CYP11B1CYP11B2HTTCYP2E1 | |
| SCHEMBL4544573 | 0.86 | CYP11B1 (0.39) | GPR119CYP11B1CYP11B2HTTCYP2E1 | |
| SCHEMBL4420132 | 0.82 | GPR119 (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL3822143 | 0.79 | CYP2E1 (0.57) | GPR119HTTCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL15899185 | 0.78 | GPR119 (0.43) | GPR119KCNH2 | |
| SCHEMBL23480267 | 0.77 | CYP11B2 (0.49) | CYP11B1CYP11B2HTTCYP2E1CYP2C8 | |
| SCHEMBL6626248 | 0.76 | CYP2E1 (0.59) | GPR119HTTCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL794054 | 0.76 | MAPT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 | |
| SCHEMBL3280017 | 0.76 | NCOA3 (0.42) | GPR119CYP11B1CYP11B2KCNH2HTT | |
| SCHEMBL14825828 | 0.76 | HTT (0.42) | GPR119KCNH2HTTCYP2E1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |