Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418437 | 0.84 | GRIN2C (0.46) | MTNR1BGRIN2CLMNAALDH1A1NPC1 | |
| SCHEMBL4423040 | 0.83 | LMNA (0.51) | MTNR1BGRIN2CLMNAALDH1A1NPC1 | |
| SCHEMBL4413412 | 0.82 | LMNA (0.51) | MTNR1BGRIN2CLMNAALDH1A1NPC1 | |
| SCHEMBL4423052 | 0.80 | GRIN2C (0.57) | MTNR1BGRIN2CLMNANPSR1 | |
| SCHEMBL4414980 | 0.78 | KMT2A (0.60) | MTNR1BGRIN2CLMNANPSR1TP53 | |
| SCHEMBL14646677 | 0.78 | ALDH1A1 (0.75) | MTNR1BLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL4423041 | 0.78 | GRIN2C (0.54) | MTNR1BGRIN2CTP53 | |
| SCHEMBL4413283 | 0.77 | MTNR1B (0.46) | MTNR1BGRIN2CTRPV1 | |
| SCHEMBL4422963 | 0.77 | GRIN2C (0.47) | MTNR1BGRIN2CLMNAALDH1A1HTT | |
| SCHEMBL4552686 | 0.77 | MTNR1B (0.45) | MTNR1BGRIN2CTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663983-B1 | N-SUBSTITUTED, 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |
| EP-1663983-B1 | N-SUBSTITUTED, 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |
| EP-1489071-A1 | N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators | 4SC AG (DE) | 2004-12-22 | — | — | EP | disclosed |