Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 5/20 | 0.41 |
| ▸ | RARB | P10826 | 5/20 | 0.41 |
| ▸ | RARG | P13631 | 5/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | BLVRB | P30043 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616063 | 0.78 | RARB (0.54) | RXRARXRBNPC1RAB9ARARA | |
| SCHEMBL1615388 | 0.77 | RARB (0.64) | RXRARXRBRARARARBRARG | |
| SCHEMBL1615150 | 0.73 | RXRA (0.58) | RXRARXRBRARARARBRARG | |
| SCHEMBL1616060 | 0.72 | RAB9A (0.48) | RXRARXRBNPC1RAB9ARARA | |
| SCHEMBL1615545 | 0.72 | RARA (0.46) | RXRARXRBNPC1RAB9ARARA | |
| SCHEMBL4419817 | 0.71 | CYP26A1 (0.50) | RXRARXRBRARARARBRARG | |
| SCHEMBL1615210 | 0.71 | RARA (0.53) | RXRARXRBRARARARBRARG | |
| SCHEMBL1615798 | 0.70 | CYP3A4 (0.51) | RXRARXRBNPC1RAB9ARARA | |
| SCHEMBL1616264 | 0.70 | RXRA (0.51) | RXRARXRBPPARGRARARARB | |
| SCHEMBL14057916 | 0.69 | NPC1 (0.57) | PPARGNR1H4NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692097-B1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2009-09-02 | — | — | EP | disclosed |