Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9093566 | 0.94 | MEN1 (0.48) | MEN1KMT2AGAASIGMAR1LPAR1 | |
| Bicarbonate SCHEMBL4428121 | 0.87 | GAA (0.66) | MEN1KMT2AGAASIGMAR1LPAR1 | |
| Bicarbonate SCHEMBL4424429 | 0.87 | MEN1 (0.70) | MEN1KMT2AGAASIGMAR1LMNA | |
| Bicarbonate SCHEMBL4421056 | 0.86 | MEN1 (0.56) | MEN1KMT2AGAASIGMAR1LPAR1 | |
| Bicarbonate SCHEMBL7615137 | 0.86 | SIGMAR1 (0.58) | MEN1KMT2ASIGMAR1LMNANPC1 | |
| Bicarbonate SCHEMBL4423971 | 0.86 | KMT2A (0.72) | MEN1KMT2AGAASIGMAR1LMNA | |
| Bicarbonate SCHEMBL4421862 | 0.86 | KMT2A (0.72) | MEN1KMT2AGAASIGMAR1LMNA | |
| Bicarbonate SCHEMBL4435083 | 0.85 | MEN1 (0.55) | MEN1KMT2AGAASIGMAR1LPAR1 | |
| Bicarbonate SCHEMBL4434716 | 0.85 | MEN1 (0.55) | MEN1KMT2AGAASIGMAR1LPAR1 | |
| Bicarbonate SCHEMBL8555003 | 0.85 | LMNA (0.47) | GAASIGMAR1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741700-B1 | 1-H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES AS PEST-CONTROL AGENTS | BAYER CROPSCIENCE AG (DE) | 2009-10-07 | — | — | EP | disclosed |