Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045055 | 0.81 | MAOA (0.57) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL31528101 | 0.80 | MAOB (0.55) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL14582853 | 0.78 | MAOA (0.54) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL29446267 | 0.78 | TACR2 (0.62) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL584489 | 0.78 | TACR2 (0.62) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL31359542 | 0.77 | MAOB (0.48) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL31359539 | 0.77 | MAOB (0.48) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL1128474 | 0.77 | ALOX5 (0.55) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL29754139 | 0.77 | ALOX5 (0.55) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL4419141 | 0.77 | MRGPRX4 (0.44) | RAB9ANPC1SMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240270758-A1 | PYRIDINO-OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ZHEJIANG GENFLEET THERAPEUTICS CO., LTD. (CN) | 2024-08-15 | — | — | US | disclosed |
| EP-4332105-A1 | PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-03-06 | — | — | EP | disclosed |
| CN-117222650-A | Pyridine or pyrimido-ring compound, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2022228568-A1 | PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 劲方医药科技(上海)有限公司 | 2022-11-03 | — | — | WO | disclosed |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
| CN-113950481-A | Macrocyclic compounds | 芝诺管理公司 | 2022-01-18 | — | — | CN | disclosed |
| EP-3924358-A1 | MACROCYCLIC COMPOUNDS | Zeno Management, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020185606-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. (US) | 2020-09-17 | — | — | WO | disclosed |
| WO-2020185606-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. (US) | 2020-09-17 | — | — | WO | disclosed |
| WO-2018178226-A1 | MCL-1 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2018-10-04 | — | — | WO | disclosed |
| US-7495001-B2 | Benzannelated derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| CN-1875001-A | Benzocyclolated compounds as PPAR activators | HOFFMANN LA ROCHE (CH) | 2006-12-06 | — | — | CN | disclosed |
| EP-1682507-A1 | BENZANNELATED COMPOUNDS AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049572-A1 | BENZANNELATED COMPOUNDS AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |
| US-20050096336-A1 | Benzannelated derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | MCL1, BCL9, CYC1 | RAB9A 3804/4885NPC1 722/4885SMN1; SMN2 2012/4885 |
| US-20050096336-A1 | Benzannelated derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | RAB9A 1563/4885NPC1 867/4885SMN1; SMN2 2906/4885 |
| US-20240270758-A1 | PYRIDINO-OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | KRAS, NRAS, BRAF | RAB9A 1025/4885NPC1 3286/4885SMN1; SMN2 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.