Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551472 | 0.81 | CCR5 (0.49) | CCR5NAAAKCNH2SIGMAR1NPC1 | |
| SCHEMBL4415713 | 0.75 | CCR5 (0.57) | CCR5KCNH2 | |
| SCHEMBL4416636 | 0.75 | CCR5 (0.52) | CCR5KCNH2AGTR2 | |
| SCHEMBL3761943 | 0.70 | CCR5 (0.91) | CCR5KCNH2 | |
| SCHEMBL3761945 | 0.70 | CCR5 (0.91) | CCR5KCNH2 | |
| SCHEMBL3752682 | 0.70 | CCR5 (0.85) | CCR5KCNH2 | |
| SCHEMBL3752686 | 0.70 | CCR5 (0.85) | CCR5KCNH2 | |
| SCHEMBL3756667 | 0.70 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL3756671 | 0.70 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL13052008 | 0.69 | CCR5 (0.77) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088860-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070758-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |