Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 9/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421630 | 0.81 | CCR5 (0.52) | CCR5NAAAKCNH2KMT2ANPC1 | |
| SCHEMBL14184975 | 0.79 | CCR5 (0.52) | CCR5KCNH2 | |
| SCHEMBL14185511 | 0.79 | CCR5 (0.51) | CCR5KCNH2 | |
| SCHEMBL4552101 | 0.78 | CCR5 (0.48) | CCR5KCNH2 | |
| SCHEMBL14185476 | 0.78 | CCR5 (0.48) | CCR5KCNH2 | |
| SCHEMBL14185475 | 0.78 | CCR5 (0.54) | CCR5KCNH2 | |
| SCHEMBL4552231 | 0.78 | CCR5 (0.48) | CCR5KCNH2HSD11B1 | |
| SCHEMBL4552911 | 0.75 | CCR5 (0.50) | CCR5KCNH2 | |
| SCHEMBL4390881 | 0.71 | CCR5 (0.53) | CCR5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4415713 | 0.68 | CCR5 (0.57) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088860-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070758-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |