Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224275 | 0.95 | OPRM1 (0.47) | OPRM1OPRL1OPRK1 | |
| SCHEMBL1928274 | 0.82 | EPHX1 (0.45) | ALDH1A1 | |
| SCHEMBL1929465 | 0.79 | CHRM1 (0.51) | OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL1929168 | 0.76 | OPRM1 (0.38) | OPRM1OPRL1GRM5OPRK1 | |
| SCHEMBL4424598 | 0.71 | OPRM1 (0.45) | OPRM1OPRL1 | |
| SCHEMBL23806264 | 0.70 | GRM5 (0.41) | OPRM1OPRL1GRM5ALDH1A1KMT2A | |
| SCHEMBL3412261 | 0.66 | L3MBTL3 (0.33) | OPRM1OPRL1GRM5OPRK1 | |
| SCHEMBL3412257 | 0.66 | L3MBTL3 (0.33) | OPRM1OPRL1GRM5OPRK1 | |
| SCHEMBL3405677 | 0.66 | L3MBTL3 (0.33) | OPRM1OPRL1GRM5OPRK1 | |
| SCHEMBL24832949 | 0.66 | GRM5 (0.39) | GRM5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035411-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA. | Astra Zeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007142583-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA. | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |