Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 5/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422309 | 0.86 | GAA (0.52) | GAAMAPTFFAR2MEN1KMT2A | |
| SCHEMBL4433371 | 0.82 | PPARA (0.37) | GAAMAPTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL13573311 | 0.77 | GAA (0.53) | GAAMAPTFFAR2MEN1KMT2A | |
| SCHEMBL4555464 | 0.74 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2SCD | |
| SCHEMBL4284053 | 0.73 | GAA (0.57) | GAAMAPTFFAR2MEN1KMT2A | |
| SCHEMBL3664740 | 0.72 | SMN1; SMN2 (0.54) | MAPTMEN1KMT2ATP53LMNA | |
| Hydrochloric Acid SCHEMBL4276562 | 0.72 | GAA (0.56) | GAAMAPTFFAR2MEN1KMT2A | |
| SCHEMBL4553190 | 0.72 | LMNA (0.46) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3666730 | 0.72 | KDM1A (0.43) | — | |
| SCHEMBL31237167 | 0.71 | NPC1 (0.63) | GAAMAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |