Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433374 | 0.87 | GPR52 (0.36) | PPARAGPR52XDHPPARGPPARD | |
| SCHEMBL4422304 | 0.82 | GAA (0.54) | LMNAMAPTSMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL13573316 | 0.77 | ESR2 (0.48) | HTTSMN1; SMN2 | |
| SCHEMBL4277759 | 0.74 | PTGER1 (0.48) | GPR52XDHKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4279956 | 0.73 | PTGER1 (0.48) | GPR52XDHKDM4EALDH1A1LMNA | |
| SCHEMBL4425377 | 0.73 | SCD (0.38) | GPR52MAPT | |
| SCHEMBL4022471 | 0.71 | PTGDR2 (0.39) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL4285070 | 0.71 | GPR52 (0.50) | GPR52XDHKDM4EALDH1A1LMNA | |
| SCHEMBL4555464 | 0.71 | LMNA (0.47) | KDM4EALDH1A1LMNAHPGDHTT | |
| SCHEMBL26133355 | 0.70 | RAB9A (0.47) | LMNAHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |