Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LHCGR | P22888 | 6/20 | 0.41 |
| ▸ | FSHR | P23945 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425812 | 0.90 | LHCGR (0.49) | JAK3LHCGRFSHRTSHRMAP4K4 | |
| SCHEMBL4425074 | 0.89 | LHCGR (0.45) | LHCGRFSHRTSHRMAP4K4BRAF | |
| SCHEMBL4423532 | 0.84 | MAP4K4 (0.51) | JAK3MAP4K4LMNA | |
| SCHEMBL4425814 | 0.83 | LHCGR (0.40) | JAK3LHCGRFSHRTSHRMAP4K4 | |
| SCHEMBL4432379 | 0.82 | LHCGR (0.43) | LHCGRFSHRTSHRMAP4K4BRAF | |
| SCHEMBL5034074 | 0.81 | LHCGR (0.51) | LHCGRFSHRTSHRMAP4K4LMNA | |
| SCHEMBL4423903 | 0.81 | LHCGR (0.54) | LHCGRFSHRTSHRBRAFKMT2A | |
| SCHEMBL5024555 | 0.81 | LHCGR (0.55) | LHCGRFSHRTSHRBRAF | |
| SCHEMBL4418728 | 0.79 | LHCGR (0.57) | LHCGRTSHRBRAFMAPT | |
| SCHEMBL5028843 | 0.76 | LHCGR (0.72) | LHCGRFSHRTSHRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618963-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2009-11-17 | — | — | US | disclosed |
| EP-1886999-A2 | Bicyclic heteroaromatic compound | N.V. Organon (NL) | 2008-02-13 | — | — | EP | disclosed |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-08-23 | — | — | US | disclosed |
| US-7229990-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-06-12 | — | — | US | disclosed |
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | MERCK SHARP & DOHME B.V. (NL) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | JAK3 3002/4885LHCGR 13/4885FSHR 3/4885 |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | JAK3 2306/4885LHCGR 10/4885FSHR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.