Iodofiltic Acid

Iodofiltic Acid

SCHEMBL4422557

C[C@@H](CCCCCCCCCCCCc1ccc(I)cc1)CC(=O)O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
S1PR2 O95136 4/20 0.50
S1PR1 P21453 4/20 0.50
S1PR3 Q99500 3/20 0.43
S1PR4 O95977 2/20 0.43
ALB P02768 2/20 0.43
ALDH1A1 P00352 1/20 0.41
TRPA1 O75762 1/20 0.41
SIGMAR1 Q99720 2/20 0.40
OXER1 Q8TDS5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodofiltic Acid SCHEMBL4422554 1.00 S1PR2 (0.50) S1PR2S1PR1S1PR3S1PR4ALB
Iodofiltic Acid SCHEMBL289760 1.00 S1PR2 (0.50) S1PR2S1PR1S1PR3S1PR4ALB
SCHEMBL5033209 1.00 S1PR2 (0.50) S1PR2S1PR1S1PR3S1PR4ALB
SCHEMBL25954990 0.87 MMP12 (0.45) S1PR2S1PR1
SCHEMBL10925462 0.87 MAPT (0.50) S1PR2S1PR1S1PR3ALBALDH1A1
SCHEMBL10925065 0.87 MAPT (0.54) S1PR2S1PR1S1PR3ALB
SCHEMBL5809402 0.87 MAPT (0.54) S1PR2S1PR1S1PR3ALB
SCHEMBL14016007 0.86 MAPT (0.56) S1PR2S1PR1ALDH1A1TRPA1OXER1
SCHEMBL5074784 0.86 MAPT (0.56) S1PR2S1PR1ALDH1A1TRPA1OXER1
SCHEMBL23983038 0.85 S1PR2 (0.50) S1PR2S1PR1S1PR3S1PR4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871179-B2 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid THE GENERAL HOSPITAL CORPORATION (US) 2014-10-28 US disclosed
US-20130052129-A1 METHOD FOR MONITORING BLOOD FLOW AND METABOLIC UPTAKE IN TISSUE WITH RADIOLABELED ALKANOIC ACID THE GENERAL HOSPITAL CORPORATION (US) 2013-02-28 US disclosed
US-8309053-B2 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid THE GENERAL HOSPITAL CORPORATION (US) 2012-11-13 US disclosed
US-8268291-B2 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid THE GENERAL HOSPITAL CORPORATION (US) 2012-09-18 US disclosed
US-7494642-B2 Fatty acid derivatives; tissue-targeted therapy; tomography; cardiovascular disorders; liver disorders; kits THE GENERAL HOSPITAL CORPORATION (US) 2009-02-24 US disclosed
US-20080213178-A1 Using a radiolabeled fatty acid analog such as endo-[18F] fluoro- or [123I]iodo-3,4-cyclopropylheptadecanoic acid localized in tissue of interest, imaging, determining blood flow rate THE GENERAL HOSPITAL CORPORATION (US) 2008-09-04 US disclosed
US-20080213173-A1 Labeled fatty acid analogs; tissue-targeted therapy; tomography; block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest such as heart, liver, or tumor; endo-vinylic variants of cycloalkyl-substituted heptadecanoic acid for example THE GENERAL HOSPITAL CORPORATION (US) 2008-09-04 US disclosed
US-20080214853-A1 Labeled cycloalkylidene-containing fatty acid analogs; tissue-targeted therapy; tomography; block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest such as heart or tumor THE GENERAL HOSPITAL CORPORATION (US) 2008-09-04 US disclosed
US-20080214851-A1 Synthesis of labeled fatty acid analogs for use in tomography THE GENERAL HOSPITAL CORPORATION (US) 2008-09-04 US disclosed
EP-1622602-B1 METHOD FOR MONITORING BLOOD FLOW AND METABOLIC UPTAKE IN TISSUE WITH RADIOLABELED ALKANOIC ACID GEN HOSPITAL CORP (US) 2008-08-20 EP disclosed
US-20040253177-A1 Fatty acid derivatives; tissue-targeted therapy; tomography; cardiovascular disorders; liver disorders; kits GENERAL HOSPITAL CORPORATION, THE 2004-12-16 US disclosed
EP-1067103-B1 Process for producing halogenated benzene compound SUMITOMO CHEMICAL CO (JP) 2003-03-12 EP disclosed
EP-0832654-B1 Radiation protection agents suitable for use with radiopharmaceuticals comprising reducible active ingredients NIHON MEDIPHYSICS CO LTD (JP) 2003-01-15 EP disclosed
US-6437103-B1 RADIOIMAGING AGENTS WHICH EXHIBIT HIGH UPTAKE AND RETENTION IN THE MYOCARDIUM; RADIOLABELED FATTY ACID MOLECULE IS AVAILABLE OR FREE OF BONDING AND THUS RETAINS THE TRANSPORT AND BIOCHEMICAL PROPERTIES BIOSTREAM INC. 2002-08-20 US disclosed
EP-1173226-A2 FATTY ACID ANALOGS FOR DIAGNOSIS OF CORONARY ARTERY DISEASE Biostream, Inc. (US) 2002-01-23 EP disclosed
US-6307045-B1 REACTING AN ORGANOMETALLIC COMPOUND WITH A HALIDE ION UNDER LIGHT IRRADIATION CONDITIONS IN THE PRESENCE OF A SEMICONDUCTOR CATALYST WITH A PHOTOCATALYTIC ACTIVITY. SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-10-23 US disclosed
EP-1067103-A2 Process for producing halogenated benzene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-01-10 EP disclosed
WO-2000061196-A2 FATTY ACID ANALOGS FOR DIAGNOSIS OF CORONARY ARTERY DISEASE BIOSTREAM, INC. (US) 2000-10-19 WO disclosed
US-6027710-A PROTECTS THE ACTIVE INGREDIENT OF RADIOPHARMACEUTICALS AGAINST THE RADIOLYSIS CAUSED BY A REACTION OF THE ACTIVE INGREDIENT WITH WATER RADICALS FORMED BY RADIOLYSIS WITHOUT DECOMPOSING THE REACTIVE ACTIVE INGREDIENT (REDUCIBLE) NIHON MEDI-PHYSISCS CO., LTD. (JP) 2000-02-22 US disclosed
EP-0832654-A2 Radiation-protecting agent NIHON MEDI-PHYSICS Co., Ltd. (JP) 1998-04-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130052129-A1 METHOD FOR MONITORING BLOOD FLOW AND METABOLIC UPTAKE IN TISSUE WITH RADIOLABELED ALKANOIC ACID FABP3, FABP1, SLC27A2 S1PR2 190/4885S1PR1 247/4885S1PR3 156/4885
US-20080214851-A1 Synthesis of labeled fatty acid analogs for use in tomography FFAR4, FFAR3, FFAR2 S1PR2 310/4885S1PR1 383/4885S1PR3 238/4885
US-20080214853-A1 Labeled cycloalkylidene-containing fatty acid analogs; tissue-targeted therapy; tomography; block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest such as heart or tumor FABP3, FFAR2, FFAR1 S1PR2 186/4885S1PR1 287/4885S1PR3 195/4885
US-20080213173-A1 Labeled fatty acid analogs; tissue-targeted therapy; tomography; block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest such as heart, liver, or tumor; endo-vinylic variants of cycloalkyl-substituted heptadecanoic acid for example FABP3, FABP1, FFAR2 S1PR2 250/4885S1PR1 351/4885S1PR3 270/4885
US-20080213178-A1 Using a radiolabeled fatty acid analog such as endo-[18F] fluoro- or [123I]iodo-3,4-cyclopropylheptadecanoic acid localized in tissue of interest, imaging, determining blood flow rate FFAR3, FFAR2, FFAR1 S1PR2 97/4885S1PR1 123/4885S1PR3 67/4885
US-20040253177-A1 Fatty acid derivatives; tissue-targeted therapy; tomography; cardiovascular disorders; liver disorders; kits FABP1, FABP3, FFAR2 S1PR2 305/4885S1PR1 391/4885S1PR3 269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.