Sugi Predict

Sugi Predict / Compounds / SCHEMBL4422704

SCHEMBL4422704

SCHEMBL4422704

COc1cc(Cl)ccc1CBr

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.46
▸ SLC6A4 P31645 5/20 0.43
▸ SLC6A2 P23975 4/20 0.43
▸ SLC6A3 Q01959 2/20 0.43
▸ KCNH2 Q12809 2/20 0.43
▸ PTGES2 Q9H7Z7 3/20 0.42
▸ GAA P10253 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ HTR2A P28223 2/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ KDM4C Q9H3R0 1/20 0.41
▸ TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3212164 0.84 KDM4E (0.47) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL11313806 0.83 MAPT (0.59) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL8151401 0.82 TRPV4 (0.52) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL2152147 0.82 TTR (0.47) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL17449713 0.81 MC4R (0.44) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL7666763 0.80 TRPV4 (0.50) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL1679612 0.80 PDCD1 (0.50) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL25735778 0.80 TRPV4 (0.46) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL29825398 0.80 PDCD1 (0.50) TRPV4SLC6A4SLC6A2SLC6A3KCNH2
SCHEMBL1306371 0.80 TRPV4 (0.46) TRPV4SLC6A4SLC6A2SLC6A3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD. (CN) 2025-04-03 — — US disclosed
CN-119343339-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-01-21 — — CN disclosed
EP-4469444-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2024-12-04 — — EP disclosed
CN-118791436-A 2-Aminopyrimidine derivative and preparation method and application thereof 中国科学院上海药物研究所 2024-10-18 — — CN disclosed
EP-4271672-A1 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2023-11-08 — — EP disclosed
WO-2023138684-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO , INC. (US) 2023-07-27 — — WO disclosed
US-11708364-B2 Azaindole derivatives and their use as ERK kinase inhibitors AGV DISCOVERY (FR) 2023-07-25 — — US disclosed
US-11708364-B2 Azaindole derivatives and their use as ERK kinase inhibitors AGV DISCOVERY (FR) 2023-07-25 — — US disclosed
US-11708364-B2 Azaindole derivatives and their use as ERK kinase inhibitors AGV DISCOVERY (FR) 2023-07-25 — — US disclosed
WO-2022225941-A1 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-10-27 — — WO disclosed
US-6939888-B2 1-H-3-arylpirrolidine-2,4-dione derivatives BAYER AKTIENGESELLSCHAFT (DE) 2005-09-06 — — US disclosed
US-20040019061-A1 1-H-3-arylpirrolidine-2,4-dione derivatives FISCHER REINER (DE) 2004-01-29 — — US disclosed
US-6472419-B1 1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents BAYER AKTIENGESELLSCHAFT (DE) 2002-10-29 — — US disclosed
CN-1080258-C 1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pesticides BAYER AG (DE) 2002-03-06 — — CN disclosed
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 — — EP disclosed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 — — WO disclosed
EP-0741700-A1 1-H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES AS PEST-CONTROL AGENTS BAYER AG (DE) 1996-11-13 — — EP disclosed
WO-1995020572-A1 1-H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES AS PEST-CONTROL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1995-08-03 — — WO disclosed
US-4447651-A 1,4-Bis-(4-chloro-2-methoxystyryl)-benzene BAYER AKTIENGESELLSCHAFT (DE) 1984-05-08 — — US disclosed
EP-0065125-A2 1,4-Bis-(4-chloro-2-methoxystyryl) benzene as well as its use as an optical brightener for macro-molecular organic materials BAYER AG (DE) 1982-11-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR TRPV4 738/4885SLC6A4 1160/4885SLC6A2 1998/4885
US-20040019061-A1 1-H-3-arylpirrolidine-2,4-dione derivatives PRXL2A, DDT, CYP4B1 TRPV4 2138/4885SLC6A4 4564/4885SLC6A2 4632/4885
US-11708364-B2 Azaindole derivatives and their use as ERK kinase inhibitors MAPKAPK2, MAPK1, MAPK3 TRPV4 2631/4885SLC6A4 2247/4885SLC6A2 1318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.