Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 9/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13598879 | 1.00 | AR (0.37) | ARTP53TRPM8USP30PGR | |
| SCHEMBL4421183 | 0.92 | AR (0.43) | ARTP53TRPM8USP30PGR | |
| SCHEMBL6025293 | 0.76 | AR (0.57) | ARPGR | |
| SCHEMBL2956204 | 0.76 | AR (0.57) | ARPGR | |
| SCHEMBL4422890 | 0.73 | PDK1 (0.43) | ARPGR | |
| SCHEMBL204731 | 0.71 | JAK3 (0.37) | ARPGR | |
| SCHEMBL4423603 | 0.68 | AR (0.48) | AR | |
| SCHEMBL6094398 | 0.68 | AR (0.48) | AR | |
| SCHEMBL13216320 | 0.67 | AR (0.67) | ARPGR | |
| SCHEMBL2963011 | 0.67 | AR (0.67) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | claimed |
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1567487-A4 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1567487-A2 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20050059652-A1 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-17 | — | — | US | disclosed |
| WO-2004045518-A2 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059652-A1 | Open chain prolyl urea-related modulators of androgen receptor function | AR, SHBG, ESRRA | AR 1/4885TP53 947/4885TRPM8 4322/4885 |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | SHBG, ESRRA, AR | AR 3/4885TP53 1159/4885TRPM8 4237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.