Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CASP6 | P55212 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168849 | 0.86 | KMT2A (0.76) | KMT2AMEN1NR1H3ALDH1A1CASP6 | |
| SCHEMBL30758650 | 0.86 | KMT2A (0.76) | KMT2AMEN1NR1H3ALDH1A1CASP6 | |
| SCHEMBL27313154 | 0.76 | ALDH1A1 (0.60) | KMT2AMEN1NR1H3ALDH1A1KDM4E | |
| SCHEMBL30758585 | 0.75 | ALDH1A1 (0.55) | KMT2AMEN1NR1H3ALDH1A1NR1H2 | |
| SCHEMBL29168848 | 0.75 | ALDH1A1 (0.55) | KMT2AMEN1NR1H3ALDH1A1NR1H2 | |
| SCHEMBL2890255 | 0.74 | KMT2A (0.56) | KMT2AMEN1NR1H3ALDH1A1CASP6 | |
| SCHEMBL17950974 | 0.74 | KMT2A (0.60) | KMT2AMEN1NR1H3ALDH1A1CASP6 | |
| SCHEMBL4649466 | 0.73 | POLB (0.65) | KMT2AMEN1NR1H3ALDH1A1GAA | |
| SCHEMBL7491552 | 0.72 | KDM4E (0.49) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL6968611 | 0.72 | G6PD (0.59) | KMT2AMEN1NR1H3ALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746989-A4 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR THE TREATMENT AND MANAGEMENT OF MYELOPROLIFERATIVE DISEASES | CELGENE CORP (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1746989-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR THE TREATMENT AND MANAGEMENT OF MYELOPROLIFERATIVE DISEASES | CELGENE CORPORATION (US) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005112917-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR THE TREATMENT AND MANAGEMENT OF MYELOPROLIFERATIVE DISEASES | CELGENE CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |