SCHEMBL442453

SCHEMBL442453

COC(=O)C(C)(N)CC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
ADRA1A P35348 1/20 0.42
KDM4E B2RXH2 1/20 0.41
CYP2C19 P33261 2/20 0.41
HIF1A Q16665 2/20 0.41
TSHR P16473 2/20 0.41
CYP2D6 P10635 1/20 0.41
DGAT1 O75907 1/20 0.37
FFAR1 O14842 1/20 0.37
CPT2 P23786 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KCNN4 O15554 1/20 0.33
GGT1 P19440 1/20 0.33
ALDH1A1 P00352 1/20 0.32
S1PR1 P21453 2/20 0.32
EGLN1 Q9GZT9 1/20 0.31
ARG1 P05089 1/20 0.31
ARG2 P78540 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8466854 0.80 HMGCR (0.41) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL6591641 0.78 ALOX15 (0.39) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL8656249 0.78 TSHR (0.59) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL8395320 0.77 DGAT1 (0.47) TSHRCYP2D6DGAT1TDP1
SCHEMBL485564 0.76
SCHEMBL161121 0.76 HMGCR (0.46) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL485077 0.76
SCHEMBL12116983 0.76
SCHEMBL16638803 0.76
SCHEMBL3117265 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 353 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2305624-B1 Self-degradable explosive device MAXAMCORP HOLDING SL (ES) 2017-09-27 EP claimed
US-8585841-B2 Systems and methods for chemical and/or mechanical remediation of nitro compounds and nitrate esters MAXAMCORP HOLDING S.L. (ES) 2013-11-19 US claimed
EP-2445852-A1 SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS Maxamcorp Holding, S.L. (ES) 2012-05-02 EP claimed
EP-2305624-A1 Self-degradable explosive formulations Maxamcorp Holding, S.L. (ES) 2011-04-06 EP claimed
US-20110041718-A1 SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS MAXAMCORP HOLDING S.L. (ES) 2011-02-24 US claimed
WO-2010149750-A1 SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS MAXAMCORP HOLDING S.L. (ES) 2010-12-29 WO claimed
EP-1773311-A1 A GASTRIC RETAINED DOSAGE FORM OF GABAPENTIN Depomed, Inc. (US) 2007-04-18 EP claimed
WO-2006015294-A1 A GASTRIC RETAINED DOSAGE FORM OF GABAPENTIN DEPOMED, INC. (US) 2006-02-09 WO claimed
WO-2006002031-A1 SUSTAINED RELEASE DOSAGE FORMS ANDRX CORPORATION (US) 2006-01-05 WO claimed
US-20050276849-A1 Sustained release dosage forms ANDRX CORPORATION 2005-12-15 US claimed
WO-2004112746-A1 CONTROLLED RELEASE-DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2004-12-29 WO claimed
US-5540945-A Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1996-07-30 US claimed
US-20240075103-A1 EXTENDED RELEASE OF NEUREGULIN FOR IMPROVED CARDIAC FUNCTION ZENSUN SHANGHAI SCIENCE & TECH CO LTD (CN) 2024-03-07 US disclosed
US-11717483-B2 Controlled release dosage form with enhanced pharmacokinetics OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT (HU) 2023-08-08 US disclosed
US-11679088-B2 Controlled release dosage form OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT (HU) 2023-06-20 US disclosed
US-11638746-B2 Extended release of neuregulin for improved cardiac function ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY, CO., LTD. (CN) 2023-05-02 US disclosed
EP-0169105-A2 Controlled porosity osmotic pump MERCK & CO. INC. (US) 1986-01-22 EP disclosed
US-4484921-A Theophylline therapy utilizing osmotic delivery ALZA CORPORATION (US) 1984-11-27 US disclosed
US-4439195-A Theophylline therapy ALZA CORPORATION (US) 1984-03-27 US disclosed
US-4326525-A Osmotic device that improves delivery properties of agent in situ ALZA CORPORATION (US) 1982-04-27 US disclosed