Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thenalidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thenalidine SCHEMBL29498 | 0.90 | OPRM1 (1.00) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL2968324 | 0.77 | KCNH2 (0.54) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL19557303 | 0.74 | CHRM2 (0.71) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL6622324 | 0.74 | OPRM1 (0.70) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL3217102 | 0.74 | OPRM1 (0.59) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL29626 | 0.71 | KCNH2 (0.66) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL443443 | 0.71 | KCNH2 (0.55) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL4424873 | 0.70 | KCNH2 (0.64) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| Bamipine SCHEMBL1649707 | 0.69 | KCNH2 (0.63) | OPRM1CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL17504857 | 0.68 | CHRM1 (0.61) | OPRM1CHRM1CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757376-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2017-09-12 | — | — | US | claimed |
| EP-1641446-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | Pediamed Pharmaceuticals, Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2004112771-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | PEDIAMED PHARMACEUTICALS, INC. (US) | 2004-12-29 | — | — | WO | claimed |
| US-20040259809-A1 | Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof | PEDIAMED PHARMACEUTICALS, INC. | 2004-12-23 | — | — | US | claimed |
| US-10987365-B2 | Compositions and methods for the treatment of pain | GM PHARMACEUTICALS, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-9757376-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20170020873-A1 | PHARMACEUTICAL COMPOSITIONS | GM PHARMACEUTICALS, INC. | 2017-01-26 | — | — | US | disclosed |
| US-9463191-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150265615-A1 | PHARMACEUTICAL COMPOSITIONS | GM PHARMACEUTICALS, INC. | 2015-09-24 | — | — | US | disclosed |
| US-9050289-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20130210835-A1 | PHARMACEUTICAL COMPOSITIONS | GM PHARMACEUTICAL, INC (US) | 2013-08-15 | — | — | US | disclosed |
| US-20090325999-A1 | PERSONALIZED PHARMACEUTICAL KITS, PACKAGING AND COMPOSITIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS | JDP THERAPEUTICS, INC. | 2009-12-31 | — | — | US | disclosed |
| US-7294345-B2 | Otorhinological delivery device | SCHERING OY (FI) | 2007-11-13 | — | — | US | disclosed |
| EP-1641446-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | Pediamed Pharmaceuticals, Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| US-20060067982-A1 | Otorhinological delivery device | TIMO HAAPAKUMPU HARRI JUKARA JUHA ALA -SORVARI HEN (FI) | 2006-03-30 | — | — | US | disclosed |
| WO-2004112771-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | PEDIAMED PHARMACEUTICALS, INC. (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040259809-A1 | Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof | PEDIAMED PHARMACEUTICALS, INC. | 2004-12-23 | — | — | US | disclosed |
| WO-2004064912-A1 | AN OTORHINOLOGICAL DELIVERY DEVICE | SCHERING OY (FI) | 2004-08-05 | — | — | WO | disclosed |
| EP-1438942-A1 | An otorhinological drug delivery device | Schering Oy (FI) | 2004-07-21 | — | — | EP | disclosed |