Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Bamipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.55 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.55 |
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 8/20 | 0.54 |
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.54 |
| ▸ | HTR2B known ✓ | P41595 | 8/20 | 0.54 |
| ▸ | CCR5 known ✓ | P51681 | 3/20 | 0.51 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bamipine SCHEMBL3217102 | 0.91 | OPRM1 (0.59) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| Bamipine SCHEMBL29626 | 0.89 | KCNH2 (0.66) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| Bamipine SCHEMBL4424873 | 0.88 | KCNH2 (0.64) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| Bamipine SCHEMBL1649707 | 0.86 | KCNH2 (0.63) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| Bamipine SCHEMBL2968324 | 0.86 | KCNH2 (0.54) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| SCHEMBL4492889 | 0.80 | OPRD1 (0.61) | OPRM1 | |
| SCHEMBL3542065 | 0.78 | KCNH2 (0.56) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| SCHEMBL27703455 | 0.76 | SLC6A2 (0.54) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| SCHEMBL16307374 | 0.75 | POLB (0.57) | KCNH2DRD3CHRM1CHRM2HTR1A | |
| SCHEMBL5969496 | 0.74 | CCR5 (0.53) | KCNH2DRD3CHRM1CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227757-A1 | Formulation for dermal application | TECHNISCHE UNIVERSITAT BRAUNSCHWEIG (DE) | 2008-09-18 | — | — | US | claimed |
| US-20120064011-A1 | PREPARATION FOR EXTERNAL APPLICATION | BUBBLES AND BEYOND GMBH (DE) | 2012-03-15 | — | — | US | disclosed |
| US-20080227757-A1 | Formulation for dermal application | TECHNISCHE UNIVERSITAT BRAUNSCHWEIG (DE) | 2008-09-18 | — | — | US | disclosed |