Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PPID | Q08752 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | PPIB | P23284 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | PPIG | Q13427 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003720 | 0.95 | MAPT (0.59) | MAPTPPIDMEN1KMT2APPIB | |
| SCHEMBL12894961 | 0.87 | PPID (0.58) | MAPTPPIDMEN1KMT2APPIB | |
| SCHEMBL11187635 | 0.83 | PPID (0.54) | MAPTPPIDKMT2APPIBPPIA | |
| SCHEMBL8252663 | 0.83 | SMN1; SMN2 (0.54) | MAPTPPIDMEN1KMT2APPIB | |
| SCHEMBL4424810 | 0.82 | PPID (0.56) | MAPTPPIDMEN1KMT2APPIB | |
| SCHEMBL13274941 | 0.81 | HRH3 (0.50) | PPIDKMT2AALDH1A1KDM4EMCHR1 | |
| SCHEMBL5004061 | 0.81 | ALDH1A1 (0.54) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL16839761 | 0.81 | MAPT (0.57) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14477029 | 0.80 | PPID (0.51) | MAPTPPIDMEN1KMT2APPIB | |
| SCHEMBL13274881 | 0.80 | PPID (0.51) | MAPTPPIDMEN1KMT2APPIB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |